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KMID : 1130320180610080258
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Korean Journal of Pediatrics
2018 Volume.61 No. 8 p.258 ~ p.263
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Increased procalcitonin level is a risk factor for prolonged fever in children with Mycoplasma pneumonia
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Jeong Ji-Eun
Soh Ji-Eun
Kwak Ji-Hee
Kwak Ji-Hee
Jung Hye-Lim
Shim Jae-Won
Kim Deok-Soo
Park Moon-Soo
Shim Jung-Yeon
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Abstract
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Purpose: Macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) is characterized by prolonged fever and radiological progression despite macrolide treatment. Few studies have examined serum procalcitonin (PCT) level in children with MPP. We aimed to investigate the association of acute inflammation markers including PCT with clinical parameters in children with MPP.
Methods: A total of 147 children were recruited. The diagnosis of MPP relied on serial measurement of IgM antibody against mycoplasma and/or polymerase chain reaction. We evaluated the relationships between C-reactive protein (CRP), PCT, and lactate dehydrogenase (LDH) levels and white blood cell (WBC) counts, and clinical severity of the disease. We used multivariate logistic regression analysis to estimate the odds ratio for prolonged fever (>3 days after admission) and hospital stay (> 6 days), comparing quintiles 2?5 of the PCT levels with the lowest quintile.
Results: The serum PCT and CRP levels were higher in children with prolonged fever and hospital stay than in those with fever lasting > 3 days after admission and hospital stay > 6 days. CRP level was higher in segmental/lobar pneumonia than in bronchopneumonia. The LDH level and WBC counts were higher in children with fever lasting for >3 days before admission compared to those with fever lasting for > 3 days. The highest quintile of PCT levels was associated with a significantly higher risk of prolonged fever and/or hospital stay than the lowest quintile.
Conclusion: Serum PCT and CRP levels on admission day were associated with persistent fever and longer hospitalization in children with MPP.
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KEYWORD
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Mycoplasma pneumoniae, Pneumonia, Procalcitonin, Drug resistance, Child
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